Product Name :
LCL521 dihydrochloride
Description:
LCL521 dihydrochloride is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase).
CAS:
1226759-47-2
Molecular Weight:
665.69
Formula:
C31H54Cl2N4O7
Chemical Name:
(1R,2R)-3-{[2-(dimethylamino)acetyl]oxy}-1-(4-nitrophenyl)-2-tetradecanamidopropyl 2-(dimethylamino)acetate dihydrochloride
Smiles :
Cl.Cl.CCCCCCCCCCCCCC(=O)N[C@H](COC(=O)CN(C)C)[C@H](OC(=O)CN(C)C)C1C=CC(=CC=1)[N+]([O-])=O
InChiKey:
RGUSRMLMLNVDSF-QJCVVZHISA-N
InChi :
InChI=1S/C31H52N4O7.2ClH/c1-6-7-8-9-10-11-12-13-14-15-16-17-28(36)32-27(24-41-29(37)22-33(2)3)31(42-30(38)23-34(4)5)25-18-20-26(21-19-25)35(39)40;;/h18-21,27,31H,6-17,22-24H2,1-5H3,(H,32,36);2*1H/t27-,31-;;/m1../s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
LCL521 dihydrochloride is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase).|Product information|CAS Number: 1226759-47-2|Molecular Weight: 665.69|Formula: C31H54Cl2N4O7|Chemical Name: (1R,2R)-3-{[2-(dimethylamino)acetyl]oxy}-1-(4-nitrophenyl)-2-tetradecanamidopropyl 2-(dimethylamino)acetate dihydrochloride|Smiles: Cl.Cl.CCCCCCCCCCCCCC(=O)N[C@H](COC(=O)CN(C)C)[C@H](OC(=O)CN(C)C)C1C=CC(=CC=1)[N+]([O-])=O|InChiKey: RGUSRMLMLNVDSF-QJCVVZHISA-N|InChi: InChI=1S/C31H52N4O7.2ClH/c1-6-7-8-9-10-11-12-13-14-15-16-17-28(36)32-27(24-41-29(37)22-33(2)3)31(42-30(38)23-34(4)5)25-18-20-26(21-19-25)35(39)40;;/h18-21,27,31H,6-17,22-24H2,1-5H3,(H,32,36);2*1H/t27-,31-;;/m1.{{[Leu5]-Enkephalin} medchemexpress|{[Leu5]-Enkephalin} GPCR/G Protein|{[Leu5]-Enkephalin} Biological Activity|{[Leu5]-Enkephalin} References|{[Leu5]-Enkephalin} supplier|{[Leu5]-Enkephalin} Epigenetics} .{{Prucalopride} medchemexpress|{Prucalopride} Neuronal Signaling|{Prucalopride} Biological Activity|{Prucalopride} Formula|{Prucalopride} custom synthesis|{Prucalopride} Autophagy} /s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 20.PMID:32695810 83 mg/mL (31.29 mM; Need ultrasonic). H2O : 100 mg/mL (150.22 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|LCL521 (1 µM) acts as a potent inhibitor of cellular ACDase activity, whereas 10 µM LCL521 has an additional, decreased affect on the α-form of this enzyme. LCL521 (10µM) causes a time-dependent (1 hours and 5 hours) decrease of the α-ACDase form in MCF7 cells.|Products are for research use only. Not for human use.|