Product Name :
CD46 Recombinant Rabbit Monoclonal Antibody [JB25-49]
Predicted band size :
Observed band size :
Synonyms:
AHUS2 antibody Antigen defined by monoclonal antibody TRA 2 10 antibody Antigen identified by monoclonal antibody TRA 2 10 antibody CD46 antibody CD46 antigen antibody CD46 antigen complement regulatory protein antibody CD46 molecule antibody CD46 molecule complement regulatory protein antibody Complement membrane cofactor protein antibody MCP antibody 展开
Function :
CD46, also called membrane cofactor protein (MCP), is a transmembrane glycoprotein that exists as a non-disulfide-linked dimer. CD46 regulates the complement cascade by inhibiting C3b and C4b deposited on self tissue. CD46 is a cofactor that binds to C3b and C4b, allowing their degradation by a plasma serine protease called factor I. This function resides in the complement control protein repeats (CCPs), with CCP1-4 essential for regulation. CD46 is widely distributed on thymocytes, T cells, B cells, monocytes, granulocytes, NK cells, platelets, endothelial cells, epithelial cells, fibroblasts, placenta and sperm, but not on erythrocytes. It is the major high affinity receptor for measles virus and human herpes virus. Mouse cells ubiquitously express CRRY, which is a functional ortholog of human decay-accelerating factor (DAF; CD55) and membrane cofactor protein (MCP; CD46).
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human CD46 aa 31-80 / 392.
Species reactivity:
Human, Rat
Verify application:
WB, IF-Cell, IHC-P
Coupling :
unconjugated
Clone number:
JB25-49
RRID:
AB_3070799
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Degarelix Aliquot store at -20℃ or -80℃.Nimorazole Avoid repeated freeze / thaw cycles.PMID:23912708
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 44 kDa
Positive control :
SiHa cell lysate, PC-3M cell lysate, PC-3M, HUVEC, human colon carcinoma tissue, human colon tissue, human breast tissue, human placenta tissue, rat kidney tissue, human prostate tissue.