Product Name :
CD33 Recombinant Rabbit Monoclonal Antibody [PSH02-51]
Predicted band size :
40 kDa
Observed band size :
70 kDa
Synonyms:
CD 33 antibody CD33 antibody CD33 antigen (gp67) antibody CD33 antigen antibody CD33 molecule antibody CD33_HUMAN antibody FLJ00391 antibody gp67 antibody My9 antibody Myeloid cell surface antigen CD33 antibody 展开
Function :
CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. It binds sialic acids, therefore is a member of the SIGLEC family of lectins. CD33 can be stimulated by any molecule with sialic acid residues such as glycoproteins or glycolipids. Upon binding, the immunoreceptor tyrosine-based inhibition motif (ITIM) of CD33, present on the cytosolic portion of the protein, is phosphorylated and acts as a docking site for Src homology 2 (SH2) domain-containing proteins like SHP phosphatases. This results in a cascade that inhibits phagocytosis in the cell.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within human CD33 aa 1-282 / 364 (P20138).
Species reactivity:
Human
Verify application:
WB, IF-Cell, FC
Coupling :
unconjugated
Clone number:
PSH02-51
RRID:
AB_3072939
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Zalcitabine Aliquot store at -20℃.Dacarbazine Avoid repeated freeze / thaw cycles.PMID:23522542
Storage buffer solution:
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 40 kDa
Positive control :
TF-1 cell lysate, TF-1, THP-1.