CD33 Recombinant Rabbit Monoclonal Antibody [PSH02-50]

Product Name :
CD33 Recombinant Rabbit Monoclonal Antibody [PSH02-50]

Predicted band size :
40 kDa

Observed band size :
70 kDa

Synonyms:
CD 33 antibody CD33 antibody CD33 antigen (gp67) antibody CD33 antigen antibody CD33 molecule antibody CD33_HUMAN antibody FLJ00391 antibody gp67 antibody My9 antibody Myeloid cell surface antigen CD33 antibody 展开

Function :
CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. It binds sialic acids, therefore is a member of the SIGLEC family of lectins.Taldefgrobep alfa CD33 can be stimulated by any molecule with sialic acid residues such as glycoproteins or glycolipids. Upon binding, the immunoreceptor tyrosine-based inhibition motif (ITIM) of CD33, present on the cytosolic portion of the protein, is phosphorylated and acts as a docking site for Src homology 2 (SH2) domain-containing proteins like SHP phosphatases. This results in a cascade that inhibits phagocytosis in the cell.

Antibody Type:
Recombinant Rabbit monoclonal Antibody

Immunogen :
Recombinant protein within human CD33 aa 1-282 / 364 (P20138).

Species reactivity:
Human

Verify application:
WB, IF-Cell, FC

Coupling :
unconjugated

Clone number:
PSH02-50

RRID:
AB_3072938

Form :
Liquid

Concentration :
1ug/ul

Storage instructions:
Store at +4℃ after thawing.Doxycycline monohydrate Aliquot store at -20℃.PMID:23381626 Avoid repeated freeze / thaw cycles.

Storage buffer solution:
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Subtype:
IgG

Purification method :
Protein A affinity purified.

ELTSA :

Molecular weight :
Predicted band size: 40 kDa

Positive control :
THP-1 cell lysate, TF-1 cell lysate, HL-60 cell lysate, TF-1.

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