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D-α-Hydroxyglutaric acid disodium
CAS No. : 103404-90-6
Biological Activity：D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling[2][3][4][5].
Research Area：Cancer|Inflammation/Immunology|Neurological Disease
Targets：mTOR|Reactive Oxygen Species|Endogenous Metabolite|ATP Synthase
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Related Small Molecules:Nicotinamide N-oxide;3-Hydroxyglutaric acid-d5;DPPC-d62;SDMA-d6;2-Mercaptobenzothiazole;Chitoheptaose heptahydrochloride;N-Acetyl-L-glutamic acid-d5;(3R,5S)-3-Hydroxy Cotinine-d3;Biliverdin hydrochloride;D-Glucose-13C,d1-3;2,3-Diaminopropionic acid hydrochloride;Docosanoic acid-d3;Choline-d6 chloride;Pregnenolone monosulfate sodium;25-Hydroxycholesterol-d6;N-Acetyl-D-cysteine;Pyrroloquinoline quinone;Roridin L2;NAPQI;Imidazole
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