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Amifostine trihydrate

CAS No. : 112901-68-5

Biological Activity：Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action^[2]^[3]^[4].

Research Area：Cancer

Targets：HIF/HIF Prolyl-Hydroxylase|MDM-2/p53

Related Small Molecules:MDM2-p53-IN-15;TC-S 7009;Glucosamine-13C hydrochloride;MC-VC-PABC-SP 141;HIF1-IN-3;p53 and MDM2 proteins-interaction-inhibitor (racemic);Navtemadlin;Prolyl Hydroxylase inhibitor 1;Glucosamine-13C6,15N hydrochloride;HIF-PHD-IN-1;MD-224;Mutant p53 modulator-1;MDM2/4-p53-IN-2;MX69;p-nitro-Pifithrin-α;RG7112;AKBA;MMRi62;LW6;Anticancer agent 50;NSC59984;Pifithrin-β hydrobromide;Ivaltinostat formic;HIF-2α-IN-5;HIF-1/2α-IN-2;GEM-5;HIF-1/2α-IN-1;Tenovin-6

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