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Lenalidomide hydrochloride

CAS No. : 1243329-97-6

Biological Activity：Lenalidomide hydrochloride (CC-5013 hydrochloride), a derivative of Thalidomide, acts as molecular glue. Lenalidomide hydrochloride is an orally active immunomodulator. Lenalidomide hydrochloride (CC-5013 hydrochloride) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide hydrochloride (CC-5013 hydrochloride) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells^[2].

Research Area：Cancer|Inflammation/Immunology

Targets：Ligands for E3 Ligase|Molecular Glues

Related Small Molecules:(S,R,S)-AHPC TFA;CRBN modulator-1;NRX-252114;cIAP1 ligand 4;(S,R,S)-AHPC-Me;cIAP1 ligand 2;(R)-CR8 trihydrochloride;Avadomide;Voclosporin;NRX-252262;TMX-4100;E3 ligase Ligand 23;VH032;BC-1215;VH032-cyclopropane-F;Tasisulam;FPFT-2216;KB02-COOH

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