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Deucravacitinib

CAS No. : 1609392-27-9

Biological Activity：Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases, which selectively binds to TYK2 pseudokinase (JH2) domain (IC₅₀=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain. Deucravacitinib inhibits IL-12/23 and type I IFN pathways^[2].

Research Area：Inflammation/Immunology

Targets：IFNAR|JAK|Interleukin Related

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Epigenetics Compound Library;Immunology/Inflammation Compound Library;JAK/STAT Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Stem Cell Signaling Compound Library;FDA-Approved Drug Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Differentiation Inducing Compound Library;Reprogramming Compound Library;Pyroptosis Compound Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Anti-Liver Cancer Compound Library ;Rare Diseases Drug Library;Anti-Prostate Cancer Compound Library;Non-steroidal Anti-Inflammatory Compound Library;Cancer Stem Cells Compound Library;

Related Small Molecules:AZ-3;AX-024;JAK3/BTK-IN-1;Cirsilineol;AT9283;Benzene hexabromide;Ginsenoside F3;(E/Z)-Zotiraciclib;Perakizumab;JAK-IN-10;Baricitinib-d3;PNRI-299;JAK3-IN-6;CTX-471;Ac-YVAD-CHO;Coumermycin A1;Momelotinib-3,3,5,5-d4;SJ10542;Delgocitinib;Mulberroside A;Upadacitinib;NFAT Transcription Factor Regulator-1;IL-17A antagonist 1;Kansuinine B;Ginsenoside Rc;α7 nAchR-JAK2-STAT3 agonist 1

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