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Tesirine

CAS No. : 1595275-62-9

Biological Activity：Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity^[2].

Research Area：Cancer

Targets：DNA Alkylator/Crosslinker|Drug-Linker Conjugates for ADC

Related Small Molecules:L-Asparagine-N-Fmoc,N-beta-trityl-15N2;Val-Cit-PAB-MMAF sodium;MC-VC-PABC-SP 141;Deruxtecan analog 2;PSMA-ALB-56;Gly3-VC-PAB-MMAE;MP-PEG8-Val-Lys-Gly-7-MAD-MDCPT;Anticancer agent 11;DC10SMe;Duocarmycin TM;SPB;(Rac)-Lys-SMCC-DM1;VcMMAE;MC-Alkyl-Hydrazine Modified MMAF;Mc-MMAE;Prednimustine;Sibiromycin;DGN549-L;MC-VA-PAB-Exatecan;Lurbinectedin;MC-SN38;DBCO-(PEG2-VC-PAB-MMAE)2

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