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Fz7-21
CAS No. : 2247635-23-8
Biological Activity：Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt–β-catenin signalling and stem cell function in intestinal organoids[2].
Research Area：Cancer
Targets：Wnt
Related Small Molecules:Wnt/β-catenin agonist 1;ARUK3001185;Gallocyanine chloride;Foxy-5 TFA;Wnt/β-catenin agonist 4;JW74;IQ 1;Heparan Sulfate;ETC-159;Laduviglusib (GMP);KY-05009;HLY78;Wnt-C59;Wogonin;NCB-0846;KY-02327;Echinacoside;JW67;IWP-4;Triptonide;Prodigiosin;BML-284 hydrochloride;Astragaloside I;β-catenin-IN-3;NLS-StAx-h;FzM1.8;KY19382;NSC668036
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