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ML221
CAS No. : 877636-42-5
Biological Activity：ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.
Research Area：Neurological Disease
Targets：Apelin Receptor (APJ)
Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Targeted Diversity Library;
Related Small Molecules:Apelin-13 TFA;ML233;[Pyr1]-Apelin-13;APJ receptor agonist 5;APJ receptor agonist 1;ELA-11(human) TFA;NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal);AM-8123;Elabela(19-32) TFA;MM 07;APJ receptor agonist 4;ELA-32(human) TFA;Azelaprag;ELA-21 (human);APJ receptor agonist 6;MM 54;CMF019;NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal);Apelin agonist 1;APJ receptor agonist 3
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