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S1P1 agonist III

CAS No. : 1324003-64-6

Biological Activity：S1P1 Agonist III is a potent and orally active S1P1 agonist with EC50 of 18 nM; no activity on S1P3.
IC50 value: 18 nM(EC50) [1]
Target: S1P1 agonist
When dosed orally at 1 and 3 mg/kg, the azahydroxymethyl analogue 22(HY-12835) achieved statistically significant lowering of circulating blood lymphocytes 24 h postdose. In rats, a dose-proportional increase in exposure was measured when 22(HY-12835) was dosed orally at 2 and 100 mg/kg. 22 displayed excellent pharmacokinetic parameters with low clearance (CL = 0.11 L/h/kg), long mean residence time (40 h), and good oral bioavailability (F = 67%).

Research Area：Inflammation/Immunology

Targets：LPL Receptor

Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Immunology/Inflammation Compound Library;Covalent Screening Library;Orally Active Compound Library;

Related Small Molecules:GSK2018682;Ozanimod hydrochloride;BMS-986020 sodium;S1p receptor agonist 2;ONO-9780307;Siponimod hemifumarate;S1P2 antagonist 1;Ceralifimod;Ki16425;H2L 5765834;S1PR1 agonist 2;RP101442;S1PR1 agonist 1;CS-2100;ASP1126;1-Oleoyl lysophosphatidic acid;Ex26;RP-001 hydrochloride;VPC 23019;CYM-5541;LPA1 receptor antagonist 1;Autotaxin-IN-6;Zectivimod;CYM5442 hydrochloride;PF-543 Citrate;LPA2 antagonist 1;LPA2 antagonist 2

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