For research use only. We do not sell to patients.
MKC8866
CAS No. : 1338934-59-0
Biological Activity：MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29 μM in human vitro. MKC8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC50 of 0.52 μM and unstresses RPMI 8226 cells with an IC50 of 0.14 μM. MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibits prostate cancer (PCa) tumor growth[2].
Research Area：Cancer
Targets：IRE1
Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Kinase Inhibitor Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Covalent Screening Library;Endoplasmic Reticulum Stress Compound Library;Anti-Breast Cancer Compound Library;Anti-Prostate Cancer Compound Library;
Related Small Molecules:IXA4;4μ8C;GSK2850163 hydrochloride;B I09;IRE1α kinase-IN-3;IXA6;GSK2850163 (S enantiomer);IRE1α kinase-IN-5;KIRA6;MKC3946;3,6-DMAD dihydrochloride;Kira8;PAIR2;IRE1α kinase-IN-2;Toyocamycin;IRE1α kinase-IN-4;KIRA-7;KIRA9;STF-083010;IRE1α kinase-IN-1;MKC9989
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
About Us:
- MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use；
- Structurally and synthetically diverse biologically active compounds；
- roduct quality is the key to our success and we take pride in offering only the highest-grade products.；
- We provide HNMR, LC-MS, HPLC, stability testing and activity assays of our products to clients.；
- Product identity, quality, purity and activity are assured by our robust quality control programs and procedures.；
- Customized order volume ranging from milligrams to kilograms scale；
Structurally and synthetically diverse biologically active compounds；
We provide customer-oriented services. To explore more, please contact us at [email protected]. Our team will gladly assist you.
