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MSA-2
CAS No. : 129425-81-6
Biological Activity：MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models[2].
Research Area：Cancer|Inflammation/Immunology
Targets：STING
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Anti-Cancer Compound Library;Small Molecule Immuno-Oncology Compound Library;Orally Active Compound Library;
Related Small Molecules:STING agonist-3 trihydrochloride;BSP16;IACS-8803 diammonium;STING-IN-2;STING agonist-10;CDN-A;STING agonist-20;TAK-676;ADU-S100 ammonium salt;H-151;STING ligand-1;cGAMP;Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine;diABZI STING agonist-1;SR-717 free acid;JAK-IN-23;Ulevostinag;Cyclic-di-GMP;2′,3′-cGAMP sodium;STING agonist-16;E7766 disodium;STING agonist-4;STING agonist-17;SN-001
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