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IXA4

CAS No. : 1185329-96-7

Biological Activity：IXA4 is a highly selective, non-toxic IRE1/XBP1s activator. IXA4 activates IRE1/XBP1s signaling without globally activating the unfolded protein response (UPR) or other stress-responsive signaling pathways (e.g., the heat shock response or oxidative stress response). IXA4 reduces secretion of APP through IRE1 activation.

Research Area：Neurological Disease

Targets：IRE1

Related Screening Libraries:Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Kinase Inhibitor Library;Anti-Aging Compound Library;Oxygen Sensing Compound Library;Endoplasmic Reticulum Stress Compound Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;

Related Small Molecules:MKC8866;4μ8C;GSK2850163 hydrochloride;B I09;IRE1α kinase-IN-3;IXA6;GSK2850163 (S enantiomer);IRE1α kinase-IN-5;KIRA6;MKC3946;3,6-DMAD dihydrochloride;Kira8;PAIR2;IRE1α kinase-IN-2;Toyocamycin;IRE1α kinase-IN-4;KIRA-7;KIRA9;STF-083010;IRE1α kinase-IN-1;MKC9989

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