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Nastorazepide
CAS No. : 209219-38-5
Biological Activity：Nastorazepide (Z-360) is a selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity.
Target：CCK-2
in vitro: Z-360 binds to the gastrin/CCK-2 receptor, thereby preventing receptor activation by gastrin, a peptide hormone frequently associated with the proliferation of gastrointestinal and pancreatic tumor cells. Check for active clinical trials or closed clinical trials using this agent.
in vivo: Z-360 is a novel orally active CCK-2/gastrin receptor antagonist, significantly inhibits the growth of subcutaneous xenografts of human pancreatic tumor cells in mice, and that Z-360 combined with gemcitabine prolonged survival in a pancreatic carcinoma orthotopic xenograft mice.
Research Area：Cancer|Endocrinology
Targets：Cholecystokinin Receptor
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Related Small Molecules:Loxiglumide;Gastrin I, human;(Rac)-Sograzepide;Proglumide;Lorglumide sodium salt;LY288513;Tarazepide;L-365260 hemihydrate;Mini Gastrin I, human TFA;CCK-B Receptor Antagonist 2;CI-988;Gastrin I, rat;JNJ-26070109;CHEMBL333994;Gastrin/CCK antagonist 1;Dexloxiglumide;N-acetyl CCK-(26-30) amide;Tetragastrin;Sograzepide-d3;SR 146131;Lintitript;A71623;GI 181771;Devazepide
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