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α7 nAchR-JAK2-STAT3 agonist 1
CAS No. : 2108714-20-9
Biological Activity：α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis.
Research Area：Inflammation/Immunology
Targets：JAK|nAChR|STAT|NO Synthase
Related Small Molecules:Carboxy-PTIO potassium;AZ-3;Valeriandoid F;JAK3/BTK-IN-1;Cirsilineol;Ochromycinone;AT9283;C188-9;Ciwujianoside C3;Benzene hexabromide;Spinosad;STAT3-IN-10;(E/Z)-Zotiraciclib;NOS-IN-3;Regaloside A;Pyrantel;JAK-IN-10;C188;Baricitinib-d3;JAK3-IN-6;Aminopicoline;Niclosamide monohydrate;trans-Isoferulic acid;STAT3-IN-1;STAT3 degrader-1;DETA NONOate;Coumermycin A1
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