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PDE1-IN-4

Biological Activity：PDE1-IN-4 (compound 2g) is a potent and selective PDE1 (phosphodiesterase-1) inhibitor, with IC₅₀ values of 10, 145, and 354 nM for PDE1C, PDE1A, and PDE1B, respectively. PDE1-IN-4 inhibits myofibroblast differentiation of human lung fibroblasts induced by TGF-β1. PDE1-IN-4 shows anti-fibrosis effects through the regulation of cAMP (3′,5′-cyclic adenosine monophosphate) and cGMP (3′,5′-cyclic guanosine monophosphate). PDE1-IN-4 can be used for idiopathic pulmonary fibrosis (IPF) research.

Research Area：Inflammation/Immunology

Targets：Phosphodiesterase (PDE)|Calcium Channel

Related Small Molecules:Senazodan hydrochloride;(E/Z)-HA155;Enpp/Carbonic anhydrase-IN-1;Benidipine hydrochloride;ATX inhibitor 22;CaV1.3 antagonist-1;14-Deoxyandrographolide;Carbazeran citrate;Bay 60-7550;BC11-38;(Rac)-MEM 1003;Deltarasin hydrochloride;Glaucine;Efonidipine hydrochloride monoethanolate;L-Ascorbic acid sodium salt;Brompheniramine-d6 maleate;MRS 1523;Nilvadipine;Ziritaxestat;Udenafil-d7;D159687;Lercanidipine;ITI-214;CP-060;PDE10-IN-5

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