For research use only. We do not sell to patients.

Hydroxy desmethyl Bosentan

CAS No. : 253688-62-9

Biological Activity：Hydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ET_A and ET_B receptors with K_i of 4.7 nM and 95 nM in human SMC, respectively. Bosentan can be used in treatment of pulmonary arterial hypertension^[2].

Research Area：Cardiovascular Disease

Targets：Drug Metabolite

Related Small Molecules:Nicotinamide N-oxide;4-Hydroxyphenylbutazone;Ampyrone;Resveratrol-3-O-sulfate sodium;Sonidegib metabolite M48;Isonicotinic acid;Cycloguanil hydrochloride;Hydroxytanshinone IIA;Endoxifen;Fodipir;Regorafénib N-oxyde (M2)-13C,d3;AZ7550 Mesylate;AR-13324 M1 metabolite;Thyroxine sulfate;Netupitant metabolite Monohydroxy Netupitant;(-)-(E)-Guggulsterone;Leukotriene D4;Desbutyl Lumefantrine;(R)-3-Hydroxy Midostaurin;RP101442;Paeoniflorgenin;PR-104A;HMMNI-d3;Ilaprazole sulfone

About Us:

MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use；
Structurally and synthetically diverse biologically active compounds；
roduct quality is the key to our success and we take pride in offering only the highest-grade products.；
We provide HNMR, LC-MS, HPLC, stability testing and activity assays of our products to clients.；
Product identity, quality, purity and activity are assured by our robust quality control programs and procedures.；

Structurally and synthetically diverse biologically active compounds；

Customized order volume ranging from milligrams to kilograms scale；

We provide customer-oriented services. To explore more, please contact us at [email protected]. Our team will gladly assist you.

Top Publications Citing Use of MCE Products