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CZC-25146
CAS No. : 1191911-26-8
Biological Activity：CZC-25146 is a potent and orally active LRRK2 inhibitor with IC50 values of 4.76 nM and 6.87 nM for wild-type LRRK2 and G2019S LRRK2, respectively. CZC-25146 inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2C as well. CZC-25146 prevents mutant LRRK2-induced injury of neurons in vitro. CZC-25146 exhibits relatively favorable pharmacokinetic properties in mice. CZC-25146 can increase normal α-1-antitrypsin (AAT) secretion and reduce inflammatory cytokines. CZC-25146 can be used to research Parkinson’s disease and liver diseases[2][3].
Research Area：Inflammation/Immunology|Neurological Disease
Targets：LRRK2
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Autophagy Compound Library;Orally Active Compound Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;
Related Small Molecules:LRRK2 inhibitor 1;LRRK2-IN-2;GNE0877;IKK 16;LRRK2-IN-1;EB-42486;XL01126;PFE-360;GSK2646264;PF-06454589;LRRK2-IN-5;PF-06456384 trihydrochloride;PF-06455943;LRRK2-IN-4;JH-II-127;GSK2578215A;LRRK2-IN-6;GNE-9605;GNE-7915;CZC-54252;MLi-2;Indazole;HG-10-102-01;PF-06447475
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