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GW280264X
CAS No. : 866924-39-2
Biological Activity：GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively. ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells[2].
Research Area：Cancer|Inflammation/Immunology
Targets：MMP
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Differentiation Inducing Compound Library;Anti-Pancreatic Cancer Compound Library;Angiogenesis-Related Compound Library;Anti-Liver Cancer Compound Library ;Anti-Pulmonary Fibrosis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:WAY-170523;CTTHWGFTLC, CYCLIC;Edaravone;D-Isofloridoside;Chondroitin sulfate;Ginsenoside F4;ND-336;Epitheaflagallin 3-O-gallate;Histatin 5 TFA;GI254023X;XL-784 free base;PI3K/AKT-IN-2;Diethyl-pythiDC;FN-439;ONO-4817;Isoliquiritin apioside;Anticancer agent 65;Licoricidin;Astragaloside IV;Phosphoramidon Disodium;Ilomastat;DB04760;Cipemastat;Marimastat;Dnp-PLGLWA-DArg-NH2 TFA;Cynaropicrin;Ro 31-9790
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