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GS87

CAS No. : 919936-70-2

Biological Activity：GS87 is a highly specific and potent GSK3 inhibitor with IC₅₀s of 415nM and 521nM for GSK3α and GSK3β, respectively. GS87 induces differentiation of acute myeloid leukemia (AML) cell lines by effectively activating GSK3-dependent signaling components including MAPK signaling. GS87 modulates key GSK3 target proteins involved in cell proliferation and differentiation more effectively than Lithium and SB415285 (SB). GS87 has the potential for acting as a differentiation agent for non-promyelocytic AML research.

Research Area：Cancer

Targets：GSK-3

Related Small Molecules:TCS2002;AR-A014418;GSK 3 Inhibitor IX;MeBIO;Cromolyn-d5 sodium;ZDWX-25;ARN25068;PfGSK3/PfPK6-IN-2;RGB-286638;Laduviglusib (GMP);GSK3 Substrate, α, β subunit;DIF-3;Bikinin;A 1070722;Indirubin-3′-monoxime;Indirubin-5-sulfonate;Aloisine RP106;GNF4877;Indirubin-3′-monoxime-5-sulphonic acid;ABC1183;GSK-3β inhibitor 10;Cromolyn sodium;AZD1080;TCS 21311;KY19382;CHIR-98014;BRD0209;SB 415286

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