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Tolebrutinib

CAS No. : 1971920-73-6

Biological Activity：Tolebrutinib (SAR442168) is a potent, selective, orally active and brain-penetrant inhibitor of Bruton tyrosine kinase (BTK), with IC₅₀s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively. Tolebrutinib exhibits efficacy in central nervous system immunity. Tolebrutinib can be used for the research of multiple sclerosis (MS)^[2].

Research Area：Neurological Disease

Targets：Btk

Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Clinical Compound Library;CNS-Penetrant Compound Library;Drug Repurposing Compound Library;Orally Active Compound Library;Anti-Blood Cancer Compound Library;Rare Diseases Drug Library;

Related Small Molecules:JAK3/BTK-IN-1;Elsubrutinib;ARQ 531;PF-06250112;PCI 29732;CHMFL-EGFR-202;Avitinib;RN486;GDC-0834 Racemate;Spebrutinib besylate;Vecabrutinib;BMX-IN-1;BTK-IN-16;(R)-Zanubrutinib;Pirtobrutinib;CTA056;EGFR-IN-40;QL-X-138;ACP-5862;BTK-IN-12;JAK3/BTK-IN-4;JAK3/BTK-IN-6;BTK inhibitor 20;SJF620

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