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Rolapitant
CAS No. : 552292-08-7
Biological Activity：Rolapitant (SCH619734) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model[2].
Research Area：Cancer|Neurological Disease
Targets：Neurokinin Receptor
Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Drug Repurposing Compound Library;Anti-COVID-19 Compound Library;Orally Active Compound Library;Neurotransmitter Receptor Compound Library;FDA Approved & Pharmacopeial Drug Library;Protein-protein Interaction Inhibitor Library;Chemotherapy Drug Library;EMA-Approved Drug Library;FDA-Approved Anticancer Drug Library;
Related Small Molecules:(β-Ala8)-Neurokinin A (4-10);Talnetant hydrochloride;Pavinetant;MEN11467;(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P;Vapreotide acetate;Eprazinone dihydrochloride;Orvepitant maleate;Netupitant metabolite Monohydroxy Netupitant;SB-222200;Senktide;GR 87389;Hemokinin 1, human;Neurokinin A TFA;Imnopitant dihydrochloride;[Glp6] Substance P (6-11);[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA;[Pro9]-Substance P;Befetupitant;Hemokinin 1 (mouse);Substance P Receptor Antagonist 1;(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B;Substance P (1-9);(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P;Substance P-Gly-Lys-Arg
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