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HDAC-IN-47
Biological Activity:HDAC-IN-47 is an orally active inhibitor of histone deacetylase (HDAC), with IC50s of 19.75 nM (HDAC1), 5.63 nM (HDAC2), 40.27 nM (HDAC3), 57.8 nM (HDAC2), 302.73 nM (HDAC8), respectively. HDAC-IN-47 inhibits autophagy and induces apoptosis via the Bax/Bcl-2 and caspase-3 pathways. HDAC-IN-47 arrests cell cycle at G2/M phase, and shows anti-tumor efficacy in vivo.
Research Area:Cancer
Targets:HDAC
Related Small Molecules:Pivanex;Crotonoside;MPT0B390;RSC133;HDAC1/6-IN-1;HDAC/HSP90-IN-4;JPS014;HDAC-IN-4;HDAC-IN-27;1-Alaninechlamydocin;SKLB-23bb;Tacedinaline;HPOB;HDAC-IN-28;CG347B;Tubacin;HDAC10-IN-1;HDAC6-IN-6;Resminostat;Alteminostat;Ivaltinostat formic;Crebinostat;FNDR-20123 free base;UF010;Homobutein;Ac-Lys-AMC;HDACs/mTOR Inhibitor 1;BRD73954
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