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GSK-872

CAS No. : 1346546-69-7

Biological Activity：GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC₅₀ of 1.8 nM, and inhibits kinase activity with an IC₅₀ of 1.3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury^[2]^[3].

Research Area：Inflammation/Immunology

Targets：RIP kinase

Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;NF-κB Signaling Compound Library;Transcription Factor-Targeted Library;

Related Small Molecules:RIPA-56;RIPK3-IN-2;GSK2983559 free acid;AV123;RIPK1-IN-8;RIP2 kinase inhibitor 2;RIP2 Kinase Inhibitor 4;PK68;RIPK-IN-4;TP-030-2;OD36;TP-030-1;RIPK2-IN-2;GSK3145095;Necrostatin 2;RIPK1-IN-4;RIPK1-IN-15;GSK-843;(Rac)-GSK547;RIPK2-IN-1;RIP2 kinase inhibitor 1;Kongensin A;PROTAC RIPK degrader-6;RIPK1-IN-10

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