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PF-6274484
CAS No. : 1035638-91-5
Biological Activity：PF-6274484 is a potent EGFR inhibitor with Kis of 0.14 nM and 0.18 nM for EGFR-L858R/T790M and WT EGFR, respectively. PF-6274484 inhibits EGFR-L858R/T790M autophosphorylation in H1975 tumor cells and EGFR WT in A549 tumor cells with IC50s of 6.6 and 5.8 nM, respectively.
Research Area：Cancer
Targets：EGFR
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;JAK/STAT Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Differentiation Inducing Compound Library;Anti-Hepatitis C Virus Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Anti-Prostate Cancer Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:NSC81111;pp60 (v-SRC) Autophosphorylation Site, Phosphorylated;BMS-690514;Osimertinib-13C,d3;EGFR-IN-5;FGFR2-IN-3;Genistein;Epertinib hydrochloride;UNC-CA359;Osimertinib mesylate;AV-412 free base;Nelipepimut-S;Falnidamol;HER2-IN-6;PROTAC EGFR degrader 7;CHMFL-EGFR-202;Avitinib;Naquotinib;Lavendustin A;EAI001;EGFR/HER2/CDK9-IN-2;Cyasterone;DP-C-4;Allitinib
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