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γ-Secretase modulator 12
CAS No. : 2204249-82-9
Biological Activity：γ-Secretase modulator 12 (Compound 1a) is a γ-secretase modulator that can selectively decrease amyloid-β42 (Aβ42) levels (IC50 of 0.39 µM). γ-Secretase modulator 12 can be used for Alzheimer’s disease research. γ-Secretase modulator 12 has a good brain/plasma ratio (Kp, brain = 0.72) in mice.
Research Area：Neurological Disease
Targets：γ-secretase|Amyloid-β
Related Small Molecules:β-Amyloid (13-27);γ-Secretase modulator 4;ELN318463;Saikosaponin C;β-Amyloid (1-42), (rat/mouse) (TFA);β-Amyloid (12-28) (TFA);BuChE-IN-5;Ginsenoside Rg1;MDR-1339;Crenigacestat;Aβ42-IN-1 free base;β-Amyloid (11-22);Fosciclopirox;20(S)-Ginsenoside Rg3;β-Amyloid (31-35);Aβ-IN-1;Qingyangshengenin B;JNJ-40418677;gamma-secretase modulator 3;HDAC6-IN-6;β-Amyloid (1-37) (human);CGP52411;Astrophloxine;γ-Secretase modulator 11 hydrochloride;Aβ42-IN-2;δ-Secretase inhibitor 11
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