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FNDR-20123 free base

CAS No. : 1267502-34-0

Biological Activity：FNDR-20123 free base is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC₅₀s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 free base exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC₅₀=41 nM) and sexual blood stage (IC₅₀=190 nM for male gametocytes). FNDR-20123 free base inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC₅₀=25, 29, 2, 11, and 282 nM, respectively) and inhibits Class III HDAC isoforms at nanomolar concentrations.

Research Area：Infection

Targets：Parasite|HDAC

Related Small Molecules:(+)-Isopulegol;SR9186;Antileishmanial agent-2;Azlocillin sodium salt;SQ109;Trypanothione synthetase-IN-3;Pivanex;Pyrantel;α-Terpinene;Dehydrocorydaline;Crotonoside;MPT0B390;Niclosamide monohydrate;Febrifugine dihydrochloride;Antimalarial agent 15;RSC133;Cycloguanil hydrochloride;Anti-infective agent 6;HDAC1/6-IN-1;HDAC/HSP90-IN-4;Morantel tartrate;JPS014

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