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PD146176
CAS No. : 4079-26-9
Biological Activity：PD146176 (NSC168807), a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (Ki=197 nM, IC50=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice[2][3].
Research Area：Cardiovascular Disease
Targets：Ferroptosis|Autophagy
Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Autophagy Compound Library;Anti-Cardiovascular Disease Compound Library;Ferroptosis Compound Library;Neurodegenerative Disease-related Compound Library;Human Metabolite Library;
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