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JI051
CAS No. : 2234281-75-3
Biological Activity：JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity.
Research Area：Cancer
Targets：Notch
Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Neuronal Signaling Compound Library;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Covalent Screening Library;Differentiation Inducing Compound Library;Anti-Breast Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Angiogenesis-Related Compound Library;Transcription Factor-Targeted Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Cancer Stem Cells Compound Library;
Related Small Molecules:ZLDI-8;Crenigacestat;FLI-06;Demcizumab;Notch inhibitor 1;Tarextumab;Notch 1 TFA;Bruceine D;Psoralidin;YO-01027 (GMP);Brontictuzumab;Semagacestat;BMS-983970;SAHM1 TFA;LY-411575;CB-103;Yhhu-3792;Jagged-1 (188-204) (TFA);Tangeretin;Z-Ile-Leu-aldehyde;tCFA15
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