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TAN-452

CAS No. : 892039-23-5

Biological Activity：TAN-452 is an orally active, selective peripherally acting δ-opioid receptor (DOR) antagonist with a K_i of 0.47 nM and a K_b of 0.21 nM. TAN-452 is an antagonist for μ-opioid receptor (MOR; K_i=36.56 nM and K_b=9.43 nM) and κ-opioid receptor (KOR; K_i=5.31 nM and K_b=7.18 nM). TAN-452, a derivative of Naltrindole, demonstrates low brain penetrability and attenuates morphine-induced side effects without affecting pain control.

Research Area：Neurological Disease

Targets：Opioid Receptor

Related Small Molecules:ORL1 antagonist 1;Loperamide-d6 N-Oxide;Deltorphin 2 TFA;Nalfurafine;β-Lipotropin (60-65);GSK1521498 free base;Trimebutine-d5 fumarate;Dynorphin B (1-13) (TFA);Dermorphin Analog;β-Endorphin (6-31), human;JTC-801;Valorphin;Corydaline;Matrine;Naloxonazine dihydrochloride;[Leu5]-Enkephalin;Sec-O-Glucosylhamaudol;DPDPE;EST73502;CTOP;β-Endorphin, equine;Tyr-W-MIF-1;Nociceptin (1-13), amide TFA;Morphiceptin;[Nphe1]Nociceptin(1-13)NH2;UFP-101

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