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δ-Secretase inhibitor 11
CAS No. : 842964-18-5
Biological Activity：δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer’s disease research.
Research Area：Neurological Disease
Targets：Amyloid-β|Caspase
Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Neuronal Signaling Compound Library;Pyroptosis Compound Library;Orally Active Compound Library;Anti-Alzheimer’s Disease Compound Library;Neuroprotective Compound Library;Neurodegenerative Disease-related Compound Library;
Related Small Molecules:β-Amyloid (13-27);Saikosaponin C;β-Amyloid (1-42), (rat/mouse) (TFA);β-Amyloid (12-28) (TFA);Dehydrocorydaline;BuChE-IN-5;Ginsenoside Rg1;MDR-1339;Z-DEVD-AMC;β-Amyloid (11-22);20(S)-Ginsenoside Rg3;β-Amyloid (31-35);p-nitro-Pifithrin-α;ML132;Aβ-IN-1;Qingyangshengenin B;JNJ-40418677;L67;AKN-028 acetate;HDAC6-IN-6;β-Amyloid (1-37) (human);CGP52411;Astrophloxine;Ossirene;γ-Secretase modulator 12
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