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RU-SKI 43 hydrochloride
CAS No. : 1782573-67-4
Biological Activity：RU-SKI 43 hydrochloride is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 hydrochloride reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 hydrochloride has anti-cancer activity.
Research Area：Cancer
Targets：Hedgehog
Related Screening Libraries:Bioactive Compound Library Plus;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Differentiation Inducing Compound Library;Anti-Breast Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Cancer Stem Cells Compound Library;
Related Small Molecules:RU-SKI 43;Dynarrestin;RL-0070933;SANT 2;Ciliobrevin D;TPB15;CUR61414;HSP70-IN-3;SANT-1;Hh-Ag1.5;SMANT hydrochloride;Robotnikinin;Ciliobrevin A;SMO-IN-2;RUSKI-201 dihydrochloride;JK184;MK-4101;3-epi-Vitamin D3;Neurodazine;TAK-441;Jervine;SMO-IN-3
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