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ONX-0914
CAS No. : 960374-59-8
Biological Activity：ONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 μM). ONX-0914 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1[2][3].
Research Area：Infection|Inflammation/Immunology
Targets：HIV|Bacterial|Proteasome
Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound Library;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;Antiviral Compound Library;Covalent Screening Library;Antibacterial Compound Library;Ubiquitination Compound Library;Anti-Blood Cancer Compound Library;
Related Small Molecules:Sandramycin;LLO (91-99);Gepotidacin;Calpeptin;Oritavancin;Azlocillin sodium salt;Herbimycin A;Antibacterial agent 45;Leucomycin;Isouvaretin;HIV-1 TAT (48-60);Antibacterial agent 99;Nafcillin;Antitubercular agent-28;Ochromycinone;Calpain Inhibitor VI;Seletracetam lithium;Staurosporine;HIV-IN-2;Nucleocidin
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