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CP-100356 hydrochloride

CAS No. : 142715-48-8

Biological Activity：CP-100356 hydrochloride is an orally active dual MDR1 (P-gp)/BCRP inhibitor, with an IC₅₀s of 0.5 and 1.5 µM for inhibiting MDR1-mediated Calcein-AM transport and BCRP-mediated Prazosin transport, respectively. CP-100356 hydrochloride is also a weak inhibitor of OATP1B1 (IC₅₀=∼66 µM). CP-100356 hydrochloride is devoid of inhibition against MRP2 and major human P450 enzymes (IC₅₀>15 µM).

Research Area：Metabolic Disease

Targets：P-glycoprotein|BCRP

Related Screening Libraries:Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Orally Active Compound Library;Cancer Stem Cells Compound Library;

Related Small Molecules:Biricodar;PCI 29732;P-gp inhibitor 4;Sinapine thiocyanate;Dofequidar fumarate;Triclabendazole sulfoxide;Elacridar;Coniferyl ferulate;P-gp/BCRP-IN-1;Anticancer agent 50;Valspodar;YHO-13351;P-gp inhibitor 1;Boeravinone B;Solamargine;Polyoxyethylene stearate;TTT-28;PD166326;Epoxylathyrol;Chrysosplenetin;Fumitremorgin C;UR-MB108;Zamicastat;Tariquidar;P-gp modulator 3

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