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PF15
Biological Activity：PF15 is a PROTAC connected by ligands for FLT3 kinase and CRBN. PF15 is a high selective FLT3-ITD degrader, with a DC50 of 76.7 nM. PF15 significantly inhibits the proliferation of FLT3-ITD-positive cells, can down-regulate the phosphorylation of FLT3 and STAT5. PF15 also inhibits tumor growth in mouse models and can be used in study of leukemia.
Research Area：Cancer
Targets：FLT3|PROTACs
Related Small Molecules:PROTAC Sirt2 Degrader-1;DB0614;AT9283;PROTAC VEGFR-2 degrader-2;(E/Z)-Zotiraciclib;dTAGV-1-NEG;CCT367766 formic;Crotonoside;HDAC6 degrader-1;PROTAC Axl Degrader 2;FLT3-IN-13;PhosTAC7;PDGFRα/FLT3-ITD-IN-2;MS98;FLT3/CDK4-IN-1;JPS014;PROTAC PARP1 degrader;MD-224;FKBP12 PROTAC dTAG-7;SJ10542;MS8815;HP1142;RIP2 Kinase Inhibitor 4;ENMD-2076 Tartrate;PROTAC EGFR degrader 7;SJ995973;ATH686;CC-885-CH2-PEG1-NH-CH3;dFKBP-1
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