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Firibastat
CAS No. : 648927-86-0
Biological Activity：Firibastat (QGC001), an orally active brain penetrating prodrug of EC33, is a first-in-class brain aminopeptidase A (APA) inhibitor (Ki=200 nM). Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats[2].
Research Area：Cardiovascular Disease
Targets：Aminopeptidase
Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Clinical Compound Library;CNS-Penetrant Compound Library;Drug Repurposing Compound Library;Covalent Screening Library;Anti-Cardiovascular Disease Compound Library;Orally Active Compound Library;
Related Small Molecules:ZJ43;Tosedostat;SC-22716;β-Spaglumic acid;Bestatin-d7;Puromycin aminonucleoside;Bestatin hydrochloride;Bestatin-d7 hydrochloride;LTA4H-IN-1;DG051;ARM1;TNP-470;NGR peptide Trifluoroacetate;SC-57461A;Amastatin hydrochloride;L-Leucinol;Actinonin;Aminopeptidase-IN-1;Acebilustat;HFI-142
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