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KT5720

CAS No. : 108068-98-0

Biological Activity：KT5720 is a potent, cell-permeable, specific, reversible and ATP-competitive PKA inhibitor (IC₅₀=3.3 µM). KT5720 is effective in reversing MDR1-mediated multidrug resistance. KT5720 also reduces the excitability of dorsal root ganglion (DRG) neurons by attenuating Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity and reducing intracellular Ca2⁺ concentrations. KT5720 can be used in the study of haematological malignancies as well as HCN and DRG neuron-related diseases^[2]^[3].

Research Area：Cancer|Neurological Disease

Targets：PKA

Related Small Molecules:PKI 14-22 amide,myristoylated TFA;Staurosporine;Malantide;DS89002333;Rp-8-CPT-cAMPS sodium;PF-4950834;Warangalone;STAD 2;AT13148;CCG215022;8-Bromo-cAMP sodium salt;Bilobetin;Jaspamycin;UCN-02;H-8 dihydrochloride;AT7867;H-9 Dihydrochloride;Fasudil;Sp-cAMPS sodium salt;PKI(5-22)amide;8-pCPT-2′-O-Me-cAMP-AM;Metadoxine;Kemptide;H-89;Bucladesine sodium

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