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PF 477736
CAS No. : 952021-60-2
Biological Activity：PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, it is also a Chk2 inhibitor, with a Ki of 47 nM. PF 477736 shows <100-fold selectivity for Chk1 over VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret (IC50=8 (Ki), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo[2].
Research Area：Cancer
Targets：FLT3|CDK|VEGFR|RET|Src|Aurora Kinase|FGFR|c-Fms|Checkpoint Kinase (Chk)
Related Screening Libraries:Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Epigenetics Compound Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Differentiation Inducing Compound Library;Reprogramming Compound Library;Cytoskeleton Compound Library;Chemical Probe Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Angiogenesis-Related Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:(Z)-FeCP-oxindole;DB0614;KB SRC 4;Tirbanibulin dihydrochloride;Dinaciclib;VEGFR-2-IN-24;BMS-690514;AT9283;SNS-032;CC-671;Bafetinib;PROTAC VEGFR-2 degrader-2;(E/Z)-Zotiraciclib;CDK1-IN-4;p60c-src substrate II;Henatinib;CCT-251921;BS-181;Samuraciclib hydrochloride hydrate;Crotonoside;PI3K/VEGFR2-IN-1;IHMT-TRK-284;Caffeic acid-pYEEIE TFA;T025;Flavopiridol;CDK8-IN-3;FLT3-IN-13
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