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Anticancer agent 65
CAS No. : 2407861-48-5
Biological Activity:Anticancer agent 65 (compound 4c) shows excellent activity in cancer cell lines, especially A549 cells, with an IC50 of 1.07 μM. Anticancer agent 65 induces S-phase arrest in A549 cells and increases the expression level of p53 and p21. Anticancer agent 65 causes apoptosis, ROS generation and collapse of MMP in A549 cells.
Research Area:Cancer
Targets:Reactive Oxygen Species|Bcl-2 Family|MMP|MDM-2/p53|Apoptosis
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