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PHD-1-IN-1
CAS No. : 2009343-14-8
Biological Activity：PHD-1-IN-1 is an orally active and potent HIF prolylhydroxylase domain-1 (PHD-1) inhibitor with an IC50 of 0.034 μM. PHD-1-IN-1 has a unique monodentate binding interaction with the active site Fe2+ ion and induces the formation of an “Arg367-out” pocket.
Research Area：Inflammation/Immunology|Cardiovascular Disease
Targets：HIF/HIF Prolyl-Hydroxylase
Related Screening Libraries:Bioactive Compound Library Plus;Epigenetics Compound Library;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Anti-Cardiovascular Disease Compound Library;Glutamine Metabolism Compound Library;Anti-Breast Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Angiogenesis-Related Compound Library;Transcription Factor-Targeted Library;Cancer Stem Cells Compound Library;
Related Small Molecules:TC-S 7009;Glucosamine-13C hydrochloride;HIF1-IN-3;Prolyl Hydroxylase inhibitor 1;Glucosamine-13C6,15N hydrochloride;HIF-PHD-IN-1;AKBA;LW6;HIF-2α-IN-5;HIF-1/2α-IN-2;GEM-5;HIF-1/2α-IN-1;Roxadustat;Daprodustat;Acetylarenobufagin;Zifcasiran;Acriflavine hydrochloride;BAY 87-2243;PT-2385;ZINC13466751;(Rac)-Dencichine;Enarodustat;HIF-2α-IN-6;ENMD-1198
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