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Proadifen hydrochloride
CAS No. : 62-68-0
Biological Activity：Proadifen hydrochloride is a Cytochrome P450 inhibitor (IC50 = 19μM).
IC50 value: 19μM
Target: P450
Proadifen HCl has many biochemical functions, some of which include: inhibitory effects on NOS1 (neuronal nitric oxide synthase; IC50 = 90 mM), adult mouse skeletal muscle AChR (acetyl choline receptor), hepatic drug metabolism via the CYP (cytochrome P450) system, CYP-dependent (cytochrome P450-dependent) arachidonate metabolism (90% at 50 μM), transmembrane calcium influx, and platelet thromboxane synthesis. This compound has also been shown to block KIR6.1 (ATP-sensitive inward rectifier potassium channel 8; IC50 = 4.4 mM) and stimulate endothelial cell prostacyclin production.
Research Area：Others
Targets：Cytochrome P450
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