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TL13-112

CAS No. : 2229037-19-6

Biological Activity：TL13-112 is a potent and selective ALK-PROTAC degrader and inhibits ALK activity with an IC₅₀ value of 0.14 nM. TL13-112 also prompts the degradation of additional kinases including Aurora A, FER, PTK2 and RPS6KA1 with IC₅₀ values of 8550 nM, 42.4 nM, 25.4 nM, and 677 nM, respectively. TL13-112 is comprised of the conjugation of Ceritinib (HY-15656) and the Cereblon ligand of Pomalidomide (HY-10984).

Research Area：Cancer

Targets：Anaplastic lymphoma kinase (ALK)|PROTACs

Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;

Related Small Molecules:PROTAC Sirt2 Degrader-1;DB0614;ALK-IN-9;PROTAC VEGFR-2 degrader-2;dTAGV-1-NEG;CCT367766 formic;KRCA-0008;HDAC6 degrader-1;PROTAC Axl Degrader 2;PhosTAC7;MS98;JPS014;PROTAC PARP1 degrader;MD-224;FKBP12 PROTAC dTAG-7;SJ10542;MS8815;Alectinib-d8;RIP2 Kinase Inhibitor 4;PROTAC EGFR degrader 7;SJ995973;CC-885-CH2-PEG1-NH-CH3;dFKBP-1;MI-389;BSJ-4-116;MS4078;PZ703b;DP-C-4;KB02-JQ1

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