For research use only. We do not sell to patients.
TRK-IN-12
Biological Activity：TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK (TRKG595R IC50 = 13.1 nM). TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC50 = 0.080 μM). TRK-IN-12 has shown a better inhibitory effect (IC50 = 0.646 μM) than control drug LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line.
Research Area：Cancer
Targets：Trk Receptor
Related Small Molecules:hTrkA-IN-1;IHMT-TRK-284;ANA-12;Larotrectinib sulfate;N-Acetyl-5-hydroxytryptamine;LM22B-10;D5261;N-Acetyl-5-hydroxytryptamine-d3;7,8-Dihydroxyflavone;TRK-IN-18;CH7057288;Entrectinib;Pan-Trk-IN-3;ONO-7475;AZ-23;Trk-IN-6;GNF-5837;Cyclotraxin B;TrkA-IN-1;PF-06737007;TRK II-IN-1;Trk-IN-10;Trk-IN-9;Trk-IN-1;Sacibertinib;Pan-Trk-IN-2;TRK-IN-13
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Structurally and synthetically diverse biologically active compounds；
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