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PF-5274857 hydrochloride
CAS No. : 1613439-62-5
Biological Activity：PF-5274857 hydrochloride is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-5274857 hydrochloride has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.
Research Area：Cancer
Targets：Smo
Related Small Molecules:Saikosaponin B1;MRT-10;LEQ506;RL-0070933;20(S)-Hydroxycholesterol;Sonidegib;MRT-83 hydrochloride;TPB15;CUR61414;SANT-1;SAG-d3;SMANT hydrochloride;BMS-833923;SMO-IN-2;SMO-IN-1;IHR-1;Purmorphamine (GMP);IHR-Cy3;MRT-14;MK-4101;SAG hydrochloride;DY131
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