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XY018

CAS No. : 1873358-87-2

Biological Activity：XY018 is a potent ROR-γ-selective antagonist. XY018 inhibits ROR-γ constitutive activity in 293T cells with high potency (EC₅₀, 190 nM). XY018 binds to the ROR-γ hydrophobic ligand binding domain (LBD).

Research Area：Cancer|Inflammation/Immunology

Targets：ROR

Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Small Molecule Immuno-Oncology Compound Library;Transcription Factor-Targeted Library;Nuclear Receptor Compound Library;

Related Small Molecules:RORγt inhibitor 1;GNE-6468;SR3335;RORγt inverse agonist 30;GNE-0946;RORγt inverse agonist 13;Vimirogant hydrochloride;SR2211;Bevurogant;ROR agonist-1;RORγt Inverse agonist 8;CD12681;S18-000003;RORγt inhibitor 2;RORγt inverse agonist 29;SR1001;Cedirogant;SHR168442;ARN-6039;A-9758;Cintirorgon;Nobiletin;TAK-828F;RORγt inverse agonist 26;GSK805;PF-06747711;Zilovertamab;(±)-ML 209

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