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Drospirenone

CAS No. : 67392-87-4

Biological Activity：Drospirenone(Dihydrospirorenone) is a synthetic progestin that is an analog to spironolactone.
Target: Progesterone Receptor
Drospirenone is a novel progestin under clinical development that is similar to the natural hormone progesterone, combining potent progestogenic with antimineralocorticoid and antiandrogenic activities. drospirenone was devoid of glucocorticoid activity. Both progestins did not show any antiglucocorticoid action. Furthermore, drospirenone and progesterone both showed considerable antimineralocorticoid activity and weak mineralocorticoid activity [1]. the pharmacological profile of drospirenone is more closely related to that of the natural hormone progesterone than is that of any other synthetic progestogen in use today. Therefore, drospirenone is anticipated to give rise to a number of additional health benefits both for users of oral contraceptives and hormone replacement therapy recipients [2]. The combination of 17beta-estradiol and drospirenone has a positive effect on BMD and a potentially beneficial effect on lipids. Although endometrial thickness increased slightly, the safety of the endometrium was assured, as no cases of hyperplasia or cancer occurred [3].
Clinical indications: Acne; Dysmenorrhea; Endometriosis; Female contraception; Folic acid deficiency; Premenstrual syndrome

Research Area：Endocrinology

Targets：Progesterone Receptor

Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;FDA-Approved Drug Library;Drug Repurposing Compound Library;Covalent Screening Library;Macrocyclic Compound Library;Lipid Compound Library;Endocrinology Compound Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Human Metabolite Library;Nuclear Receptor Compound Library;

Related Small Molecules:Gestonorone Capronate;Chlormadinone acetate-d6-1;17α-Hydroxyprogesterone;Nestoron;Melengestrol acetate-d2;Asoprisnil-d3;Norgestrel-d6;Progesterone-13C2;Melengestrol acetate;Progesterone;Progesterone-13C5;PF-02413873;Chlormadinone acetate;Chlormadinone acetate-d6;ARD-61;Altrenogest

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