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Chrysosplenetin
CAS No. : 603-56-5
Biological Activity：Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A.
Research Area：Metabolic Disease
Targets：Ferroptosis|P-glycoprotein|Cytochrome P450
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