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PR-104A
CAS No. : 680199-06-8
Biological Activity：PR-104A (SN 27858) is the alcohol metabolite of phosphate prodrug PR-104. PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin. Antitumor Activity. PR-104A is metabolized under hypoxia by the 1-electron NADPH:cytochrome P450 oxidoreductase. PR-104A can be used for the research of relapsed/refractory T-lineage acute lymphoblastic leukemia (T-ALL)[2].
Research Area：Cancer
Targets：Drug Metabolite|DNA Alkylator/Crosslinker
Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Covalent Screening Library;Anti-Lung Cancer Compound Library;Anti-Blood Cancer Compound Library;Drug Metabolite Library;
Related Small Molecules:Nicotinamide N-oxide;4-Hydroxyphenylbutazone;Ampyrone;Resveratrol-3-O-sulfate sodium;Sonidegib metabolite M48;Isonicotinic acid;Cycloguanil hydrochloride;Anticancer agent 11;Tesirine;DC10SMe;Hydroxytanshinone IIA;Duocarmycin TM;Endoxifen;Fodipir;Regorafénib N-oxyde (M2)-13C,d3;AZ7550 Mesylate;Prednimustine;AR-13324 M1 metabolite;Thyroxine sulfate;Sibiromycin;Netupitant metabolite Monohydroxy Netupitant;Lurbinectedin;(-)-(E)-Guggulsterone;Leukotriene D4;Desbutyl Lumefantrine;(R)-3-Hydroxy Midostaurin;RP101442
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